It’s a crisis, but nothing to do with them . . .

It’s frequently asserted that the global pharmaceutical industry is in deep trouble. Owing to the staggering cost of producing a new drug, ‘big pharma’ needs blockbusters (bestsellers that will generate vast amounts of money). These are few and far between these days, and some observers have concluded that they’ve ‘picked all the low hanging fruit’. However, the American medical culture is unique. The USA is one of only two countries (the other is New Zealand) that allow drug companies to advertise on TV. Consequently the USA is swamped with medication, and ‘big pharma’ spends billions on direct advertising to doctors, and on ensuring that regulators and politicians don’t interfere with their activities.

Since 1999, prescription pain medication has killed about 350,000 Americans, and it’s the leading cause of death among the under 50s in the USA. This is ‘the opioid epidemic’, and it’s a monumental human catastrophe. Opium-based treatments for pain were restricted until the early 1980s, when a single paper (later revealed to be based on weak data) and a short 101 word letter to a leading journal established a whopping lie: “Less than 1% of patients treated with opioids become addicted.” Drug companies now produced a range of synthetic versions of opioids, and the marketing aimed at regulators and doctors was explicit. The message was simple and very successful: “It’s irresponsible not to treat pain.”  

Several brands were involved in the crisis, but there’s a general consensus that OxyContin is a major culprit. It became available in 1996, and was issued by Purdue Pharma. OxyContin used a proprietary coating designed to offer “continuous release” (hence the “Contin”) and it was disingenuously claimed to be “less addictive”. In fact, the release mechanism made it more addictive, and anyway the coating could easily be removed. However, the Food and Drug Administration (FDA) approved OxyContin for “moderate to severe pain”, and Purdue launched an unprecedented marketing campaign. They employed almost 1,000 reps, and specifically targeted locations where two crucial factors were firmly established; there were high levels of opioid prescription and dependency was already an issue. A typical example is the destitute rural towns of Appalachia, and in one of these (population only 3,000) a single clinic legally prescribed more drugs than the whole of West Virginia’s University Hospital. Unsurprisingly some prescribers were making a fortune, and one enthusiastic doctor crammed some of his $7 million in cash into a safe deposit box.

By 2009 sales of OxyContin hit a staggering $3 billion a year, the same year that drug overdose deaths exceeded road accident fatalities in the USA. This grubby saga of corporate greed relied on blatant misrepresentation (via funded reports) to ensure that the FDA and legislative bodies didn’t interrupt the gravy train or the appalling death toll. Purdue insist that they always follow FDA rules, and they blame doctors for over-prescribing and patients for misuse. Earlier this year (2018) Purdue stopped marketing OxyContin, but 2 million Americans are addicted to opioids and heroin use has accelerated (with opioids identified as the gateway drug to heroin).

Obviously, all prescribed opioids in the US and the UK had to go through the legally required animal testing before they were approved. There are multiple causes of the epidemic, but all the deficiencies and immorality of vivisection are exposed by this tragedy. Negative animal results (in this case, pinpointing the highly addictive nature of opioids) can be ignored and then ‘manipulated’ or simply removed before data is supplied to the FDA (see notes below). The cosy relationship between the FDA and pharma companies – the revolving door syndrome – is another and not unconnected scandal.

In the USA Purdue are facing an avalanche of lawsuits, and they will (almost certainly) have to make huge compensation payments. However, these losses will be fairly insignificant against the billions generated by OxyContin. The final irony is that a new treatment for opioid addiction was recently patented in the USA, and the patent was granted to (wait for it) none other than Purdue Pharma.

Paul Freestone

 

Notes:

For a full account of the opioid epidemic, see Beth Macy, Dopesick: Dealers, Doctors and the Drug Company That Addicted America, Little, Brown and Co., 2018; also Sam Quinones, Dreamland: The True Tale of America’s Opiate Epidemic, Bloomsbury Press, 2016.

A recent article in the journal Science discusses the “incredibly alarming” practice of cherry-picking data from pre-clinical (i.e. animal) trials of drugs, and the flawed reporting of these trials to the FDA: see ‘Study questions animal efficacy data behind trials’, Science, 13 April 2018 (vol.360, p.142), accessible here: http://science.sciencemag.org/content/360/6385/142  It’s an especially shameful part of a wider problem – the failure of truly dis-interested research – which is the special theme of the journal’s issue for 21 September of this year.

Remembering and Preferring to Forget

This is a revised and updated version of a post first published on 4 November 2015. 

On Sunday, November 11th, after the remembrance services have ended in London’s Whitehall and elsewhere, a service for the other war-dead will take place at the Animals in War memorial in Park Lane (at 3 p.m.). The memorial itself was designed by the sculptor David Backhouse, and built there in 2004. Its commissioning and making were a notable achievement, giving permanent and very public recognition for the first time to the part which animals have been made to play in human wars.

In letters cut into its white Portland stone, the memorial declares “This monument blog memorialis dedicated to all the animals that served and died alongside British and Allied forces in wars and campaigns throughout time.” Officially, therefore, it remembers only the animals who sided with ‘us’, rather than all the animals who have anywhere been forced, tricked, or otherwise induced to risk their lives in war-efforts. In this respect, perhaps disappointingly, it’s a very traditional war memorial. Unlike the Brown Dog memorial to vivisected animals, located a few miles away in Battersea Park, it is not a statement of dissent.

However, at least it doesn’t glorify or sentimentalize its subject. The suffering of the animals, and their preference for freedom, are plainly shown. Burdened, crowded, unnaturally jumbled as to species like the ruin of Noah’s Ark which war indeed makes of them, they press towards a gap in the curving stone stockade and the freedom of the grass and trees beyond – a freedom actually reached and enjoyed by war_horse_bannera great bronze horse and dog. And any disingenuousness in that word “served” is properly corrected by the brief but eloquent sentence cut into the stone by itself at the far right: “They had no choice.”

Better still would have been ‘They have no choice’, reminding the visitor to this monument that ‘they’ are not simply history, but have a countless posterity today and to come. Perhaps in fact this memorial does have too much of a historical – specifically a First World War – feel about it. But then that was the war in which animals were most visibly used: not just the ubiquitous horses but, as the memorial shows, mules, camels, dogs, cats, pigeons, even elephants. But yes, horses most visibly and numerously of all. Hence that cry of distress in a letter written by the composer Edward Elgar as early as 25 August 1914: “Concerning the war I say nothing – the only thing that wrings my heart and soul is the thought of the horses – oh! my beloved animals . . . Oh, my horses.” About 1 million of the horses used by Britain and its allies on the Western Front are said to have lost their lives. Some of these horses belonged to cavalry regiments, but most had been requisitioned from farms, haulage companies, livery stables, and private owners. They knew, therefore, even less of war than the conscripted men whom they “served and died alongside”. Across the whole war, perhaps 8 million horses lost their lives.

But despite this profligate use of horses, the First World War was the one which set the style for modernity in battle, where humans and animals would be only the perishable element in a contest largely to be characterized and determined by science and machinery. And here the setting of the memorial is uncomfortably apt: not a pastoral or even a tolerably quiet scene, but Park Lane’s contribution to carmageddon, vehicles hustling past on either side (the memorial is in between the two carriage-ways), suggesting in their roar and stink that peace, in a consumerist society, is only the continuation of war in other forms and with other sorts of casualty.

There is one aspect of that war, however, about which the memorial says nothing. It was the First World War, specifically its science front, which enlisted animals into a wholly new variety of war work: weapons research. For the UK, this began in 1916 at the government’s research station on Porton Down, with the study of poison gas.

Such research is the least glorious and photogenic of all types of war service for animals to participate and die in. It offers no scope for the mutual affection and loyalty suggested in that telling word “alongside” in the text of the memorial. It won’t earn any animal the PDSA’s Dickin Medal: “For Gallantry (we also serve)”. All the more reason to give it this much recognition: a place among the representations here in Park Lane. But most unfortunately no such place is made for it. There are no images of monkeys by which to recall, for instance, their service to ‘allied forces’ on the hellish Primate Equilibrium Platforms at Brooks Air Force Base in Texas, as described by Peter Singer in Animal Liberation, or their continuing service at Porton Down, testing the fatal effects of biological agents. There are no dolphins or whales to memorialize the ways in which their kind have served in cruel and unnatural trials at the Kaneohe Bay Naval Undersea Centre near Pearl Harbour. (It was about these last experiments that the marine biologist Jacques Cousteau commented, “No sooner does man discover intelligence, than he tries to involve it in his own stupidity.”) Nor are any pigs shown on the memorial, to record the use of their deliberately injured bodies in the training of British military surgeons.

Likewise absent is any word or image to recall the hecatombs of animals put to use during and after the Second World War in research for the newly developed atomic weaponry. Even before the first test explosion at Alamogordo, New Mexico, the scientists preparing for it had enjoyed the use of “an animal farm” – mice, dogs, goats – for research into radiation. When two atomic bombs were tested at Bikini Atoll immediately after the war, a number of the so-called “ghost ships”, placed in the target area to evidence the effects of the bombs, had animals on board: pigs, goats, rats, mice. Some of the animals were shaved “so that the effects of heat and radiation on their skins could be observed.”  All of them died as a result, either at once or soon after. By the 1960s, about 5 million animals were being used every year just in research sponsored by the USA’s Atomic Energy Commission. And of course such research didn’t stop when the habit of testing bombs did. In the year before the Park Lane memorial was completed, an article in the journal Radiation Research had confirmed the continuing usefulness of such research; it was titled ‘Mortality of Atomic Bomb Survivors Predicted from Laboratory Animals’.

The exigencies of battle itself may impose cruel demands upon the animals innocently induced to take part. The Park Lane memorial records something of those demands with proper sadness and respect, if without explicit protest. But fear of war, which is what has driven the atomic research and other research into weapons of mass destruction, is an even more pitiless taskmaster. At a House of Lords committee hearing on animal research a few years ago, one witness (backing the work being done at Porton Down) spoke of the possibility that pneumonic plague might be used as an infective agent against us in war: “For an agent like that there is virtually no price not worth paying to get an effective antidote.” He meant, of course, ‘not worth their paying’. The familiar mixture of cowardice and ruthlessness in that attitude – qualities so antithetical to the conduct of war as we prefer to remember it in our memorials – perhaps explains why this aspect of the war-work of non-human animals was omitted in Park Lane. It’s simply too ignoble to be willingly remembered.

 

Notes and references:

An account of the Brown Dog memorial and its significance can be found in this blog at https://voiceforethicalresearchatoxford.wordpress.com/2015/08/07/the-brown-dog-statues/

For a short but excellent and well-illustrated account of the part horses were made to take in the First War, see Simon Butler, The War Horses: the Tragic Fate of a Million Horses Sacrificed in the First World War, Halsgrove, 2011. The numbers given above are from Butler’s book, pp.48 and 118.

Edward Elgar’s letter is quoted by Andrew Neill in ‘The Great War: Elgar and the Creative challenge’, The Elgar Journal, vol.11 no.1, March 1999, pp.9-41 (at p.12).

The Dickin Medal was instituted in 1943 by the founder of the People’s Dispensary for Sick Animals, Maria Dickin. The first recipients of it were three pigeons.

The experiments using the Primate Equilibrium Platform are described by Peter Singer in Animal Liberation (Pimlico Books, 1995; first published 1975) pp.25-29; those at Kaneohe Bay in Richard Ryder, Victims of Science (Poynter Davis, 1975), pp.79-80, where also Jacques Cousteau is quoted. Because weapons research is especially secretive, up-to-date information is not easily available, but examples of work being done for military purposes at Porton Down and also at British universities can be seen on the Animal Justice Project web-site at https://animaljusticeproject.com/the-secret-war/.

As to the nuclear research: The “animal farm” is recalled by a scientist who worked at the University of Chicago (where some of the preparatory research for the first atomic bomb was carried out), as quoted on the web-site of the Atomic Heritage Foundation, at https://www.atomicheritage.org/history/operation-crossroads . The preparing of the animals on the ships (it’s not clear how many of the ships held animals) is briefly shown and described in a documentary film made for the US Department of Energy in 1946, and titled Project Crossroads – Operation Crossroads being the name given to these first post-war atomic tests. The number 5 million is an estimate made in the 1969 pamphlet ‘Animals in Atomic Research’, published by the US atomic Energy Commission. The article in Radiation Research was published in August 2003 in vol.160, no.2, pp.159-67.

The quotation “For an agent like that …” comes from evidence given by Dr Lewis Moonie, Parliamentary Under-Secretary of State for Defence, to the Lords’ Select Committee on Animals in Scientific Procedures, April 2002.

Not mentioned in the above text is research being carried forward now, sponsored by the US Department for Veterans Affairs, in which dogs are used as models for the study of paralyzing injuries sustained in battle. These ruthless experiments are the subject of a ForceChange petition which you can sign here: https://forcechange.com/518057/stop-backing-experiments-that-mutilate-and-murder-dogs/