Brothers and Cousins

Statistics of the animal research done in Britain during 2016 have now been published. They show a decrease of about 5% or 206,000 in the annual total of ‘procedures’ (down, but not very far down, to 3.94 million). The Home Office press release announcing the statistics was headed with that notable news – notable not so much because the achievement is very great (after all, the 2015 figure had been the highest number of ‘procedures’ ever recorded), but because it represents only the second time in about fifteen years that the numbers have not gone up. And the total in 2016 is still larger than it was in 1986, when the present Animals (Scientific Procedures) Act was introduced with the aim and expectation (for a time actually realised) of pushing the numbers steadily down.

Now is a good moment to recall that aim, because the European Union’s Directive 2010/63, which has been co-ordinating the laws on animal research in all 28 member states, is about to be revised. Although the U.K. will probably not belong to the Union by the time any revisions come into effect, its own practice will certainly be influenced by them. In fact, because science is an internationally collaborative business, published in international journals, the rules and standards established in the Union are certain to have some influence in all countries where animals are used in research.

Article 58 of the Directive requires the European Commission (the E.U.’s executive) to “review” its contents no later than 10 November 2017. In doing so, the Commission must take into account “advancements in the development of alternative methods not entailing the use of animals, in particular of non-human primates”. Specifying OU primateprimates in this way, the Directive’s authors no doubt had in mind a ‘declaration’ which the European Parliament had adopted back in 2007, urging the Commission “to establish a timetable for replacing the use of all primates in scientific experiments with alternatives”. Anyway, by way of limbering up for the review, the Commission asked one of its advisory committees, the Science Committee on Health, Environmental and Emerging Risks (SCHEER), to set up a Working Group to study and report on “the need for non-human primates in biomedical research, production and testing of products and devices”. Under this same title, with its ready-made implication that such a need really does exist, SCHEER accordingly published its conclusions (formally an ‘Opinion’) a few weeks ago. These conclusions, on such an especially controversial aspect of animal research, may be taken as indicative of what animals have to hope for from the coming review.

We’re deep inside the E.U. machine here: a working group reporting to a standing committee commissioned to advise the executive on the revision of a parliamentary directive setting the parameters for (and here we at last come out into the open) actual laws in the 28 member states. And the advice itself frequently does have a machine-generated feel to it, of truth made out of words rather than real things, and all the more conveniently incontrovertible for that. “It is indeed important to consider the limitations of the NHP when choosing which species to use in a drug-safety test: the use of an appropriate species or combination of species/models is essential to obtaining the most reliable and translatable information.”[p.63] Has anything been said here that isn’t necessarily true? Is anyone arguing, for instance, that an inappropriate species would produce more reliable information? This key word ‘appropriate’, with its built-in wisdom, is much used in the authors’ proposals: “appropriate training”“appropriate standards”, and of course “appropriate use of NHPs”.

Another such passe-partout word is ‘robust’: the authors variously recommend “robust scrutiny”, “robust peer review procedures”, “robust study design”, and so on. One wonders why scientists hadn’t thought of the great merits of robustness before. Anyway, everything will surely be better in this robust and appropriate new world.

But not very much better. Distinctly this is a technical account of the subject: how to make things as they are work properly (the machine again). There are some good suggestions to that end, certainly. For instance the authors recognize, as one of the barriers to progress in animal-free research, the weight of professional habit and institutionalized practice; they advise that training courses for animal researchers should include “non-animal technologies”, so that transition is easier and more acceptable [p.64]. Also I must concede that, for all the tautologies and self-evident truths, there’s a 12-page bibliography to back up what the committee says. But the rationale for all this attention, why it matters whether there’s a ‘need’ for NHPs in science or not – in short, the morality of it – is almost untouched. Two pages (out of 66 in the main text) make a hurried tour of the topic, though it is of course alluded to from time to time elsewhere. But then all members of the Working Group were scientists. Accordingly, the page headed ‘Minority Opinion’, which looks rather promising with the whole of page 23 to itself in the table of contents, proves, when one reaches it, to be blank, apart from the word “None”.

The committee recognises, as a political fact, that “polls of the European public repeatedly show low levels of acceptance of the use of NHPs in research” [p.24]. Approval for the use of NHPs in the U.K., for instance, was about 17% when last canvassed (see, in this blog, ‘Animal Pains and Human Attitudes: the new Ipsos Mori survey’, 26 September 2016). However, there is at least “greater acceptance of animal research where animal use and suffering are minimised in line with the 3Rs principle” [i.e. Replacement, Reduction, Refinement: p.25]. This is no doubt true, although it’s a somewhat disingenuous way of putting things: where acceptance has not been ‘great’ in the first place, it shouldn’t really be said to become “greater”. And I suspect that approval would actually have been even lower if the respondents had known, as this SCHEER report records, that nearly three quarters of ‘procedures’ conducted on NHPs in the E.U. are for “regulatory use and routine production” [p.15].

What these quotations illustrate is how the “3Rs principle” is seen by scientists as a sort of ethical machine labouring away to turn expediency into good conduct, rather as the “invisible hand” of the free market was supposed by Adam Smith to convert self-interested actions into social good. In this capacity, it’s expected to satisfy or at least placate opponents of animal research. That it does not do so, and that the whole managerial attitude to “ethical considerations” understates their seriousness, is evident in the consultation document which is published alongside the SCHEER report (but which came before it in time, of course).

I must say that this 234-page consultation document is conspicuous proof at least of the diligence and fair-mindedness of the committee, which here records in the left-hand column, and replies to in the right, hundreds of queries and comments. It wasn’t in the committee’s remit to deal with ethics except as a general premise, but at least the moral passion is now allowed printed expression in raw, ungentrified form: “cruel”, “inhuman”, “abhorrent”, “nearest cousins”, “brothers”, “freedom”. True, the committee makes little attempt to address this sort of complaint (there being plenty of other more strictly scientific representations). “Stop this insane abuse!!” says one contribution (well yes, two exclamation marks, but then, as the great Aneurin Bevan used to say, “In public life, those who would change things must shout to be heard”). To such, the committee can only reply with a slightly pompous set formula: “This is a personal opinion. The comment does not provide any suggestions for improvements of the scientific basis of the SCHEER preliminary Opinion and/or any scientific evidence.” Still, such remonstrations, earnest and unscientific, are at least recorded here. Thank you to those who did speak up with this authentic human indignation.

When it issued its previous ‘opinion’ on animal research, just prior to the making of the 2010 Directive, this same science committee was called SCHER. The second ‘E’, recently added, stands for ‘emerging’, and refers to novel or reappearing infectious diseases. It’s an ominous alteration for NHPs, because this is one of the areas of research in which the committee, so far from sketching out a diminution in their use, foresees an increase. NHPs, so SCHEER claims, “provide essential models for understanding and combatting (re)emerging infectious pathogens.” Thus, for recent research into whooping cough, “a new baboon model was developed” [p.47]. That rather euphemistic phrase actually means that research was conducted, for the first time, on juvenile baboons (from two to six months old): the opposite of the 3Rs, then. SCHEER justifies such retrogressions by speaking of “realistic dangers” [p.47]. Danger, which might properly be seen as a test and validation of our ethics, is evidently expected to frighten them away. And after all, even the great apes (gorillas, chimpanzees, orangutans, bonobos), whom the E.U. Directive in principle protects absolutely from scientific exploitation, may be used “in relation to an unexpected outbreak of a life-threatening or debilitating clinical condition in human beings” [Article 55.2].

So, shall a timetable be drawn up for ending the use of NHPs in European research, as the E.U. Parliament was dreaming ten years ago? SCHEER’s 12,000 word answer resembles the one being given in a famous Saul Steinberg cartoon from 1961. A well-fed manager of some sort, comfortably leaning back at his desk, addresses a petitioner with a mass of words, illegible but obviously full of patronizing civilities and bureaucratic reassurances. The words coalesce, above the petitioner’s head, into a giant ‘NO’.

 

Notes and references:

The 2016 statistics can be viewed here:

https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/627284/annual-statistics-scientific-procedures-living-animals-2016.pdf

These new statistics record about 3,600 procedures using NHPs. The SCHEER report uses the all-E.U. figure of 8898, which was the total in 2014. Note that the Home Office numbers don’t include Northern Ireland: i.e. they cover animal research in Great Britain rather than the U.K.

The 2007 Declaration of the European Parliament on primates in scientific experiments is published online at http://ec.europa.eu/environment/chemicals/lab_animals/pdf/fische_suite.pdf

The SCHEER report is at https://ec.europa.eu/health/sites/health/files/scientific_committees/scheer/docs/scheer_o_004.pdf

The results of the public consultation are published at https://ec.europa.eu/health/sites/health/files/scientific_committees/scheer/docs/followup_cons_primates_en.pdf

Aneurin Bevan is quoted in Michael Foot, Loyalists and Loners, Collins, 1987, p.36. Among other political achievements, Bevan was the Minister of Health from 1945 to 1951, therefore the man responsible for establishing the U.K.’s National Health Service.

The photograph is of a rhesus macaque monkey in Oxford University’s Biomedical Sciences Building, and is used here by permission of the University’s Public Affairs Office.

 

 

 

 

Earth-born Companions

When Oxford University was first required to estimate its annual usage of animals in research and teaching – this was in 1875 – the tally was about 30 frogs and smaller unspecified numbers of fish, dogs, rabbits, insects. No mice were mentioned. In 2016, the University used 226 frogs but more than 200,000 mice.

I don’t know when mice overtook frogs as the leading victims of animal research. Now, in the U.K. at least and probably everywhere, they account for well over 60% of all experiments and a much higher proportion of the GM breeding programmes. A huge industry and international trade has come into being, devoted to the creation and exchange of genetically altered mice. Two of its primary sites are the Medical Research Council’s establishment at Harwell in the U.K., and the Jackson Laboratory in the U.S.A.

As well as its own research, MRC Harwell supplies mice to other laboratories round the world, either live or as frozen sperm or embryos (see web-site for prices). In more detail, its services include (just to give an idea of the sort of thing) “Production of blastocysts and pseudo-pregnant females [a blastocyst is a cluster of cells in the very early stage of embryo development]… Uterine transfer of injected blastocysts to pseudo-pregnant foster-mothers [the foster-mother is the female into whom the foetuses extracted from the first mother are inserted. Neither mother survives the process] … Oviduct transfer of injected embryos to pseudo-pregnant foster mothers … Harvest and preparation of F0 transgenic embryos …”, and so on. The gruesome gynaecology of all this, I won’t attempt to describe: a sample guide to one of the procedures, with illustrations, is referenced below. MRC Harwell bred over 213,000 mice in 2016, but this number would not include the mice archived or traded in unborn condition, or the wastage in mothers and unviable offspring.

The Jackson Laboratory, based in Bar Harbor, Maine, does things on an even larger scale. Like Harwell, it does its own research work. In addition, more than 3 million ‘Jax’ mice, from a selection of over 7000 genetically defined varieties, are sent out to other institutions.

A brief digression now on the likely experiences of these Jax mice at their destinations. Since the Jackson Laboratory receives state funding, it has to conform to national guidance as to the care of its own animals. The same does not apply to the privately funded or commercial laboratories in the U.S.A., well over 800 of them, to which Jax mice may be sent (still less, of course, to laboratories in other countries). These establishments are regulated only by the Animal Welfare Act, whose definition of ‘animal’ does not include mice (or rats or birds). This glaring anomaly is genially described as a “quirk” by the National Academy of Sciences, but actually it was a very deliberate omission, and one which was later emphatically fixed into law by the so-called ‘Helms Amendment’ of 2002. Senator Jesse Helms pointed out to his fellow-senators during the debate that a mouse was much better off in a laboratory than being eaten by a python in the wild, and evidently they accepted this as a useful bench-mark for mouse-welfare. Certainly the research industry did; indeed it had sponsored Helms’s intervention. This is just one instance of a consistent historical record. In spite of all the claims in their publicity to be making animal welfare their special concern, research institutions and their agencies have always resisted statutory controls. If they’d had their way, laboratory animals would even now be relying for their welfare wholly on the haphazard kindness of their vivisectors.

Back to the Jackson Laboratory, and the man who founded it in the 1920s, Clarence Little. In later years he declared that his institution “has done for the mouse in science what Disney has done for it in amusement.” In fact he hoped that Walt Disney’s version of the mouse might be employed to publicize medical research of the Jackson sort – rather Mickey_-_House_of_Mouseas comic pigs advertise bacon. And certainly Micky Mouse would very expressively have represented what has happened to the mouse since it got caught up in medical research. The Disney studio ruthlessly stylized Mickey Mouse, both to make repeat drawing easier, and to make him highly visible and recognisable (the strange white gloves and bulbous shoes, for instance): this is the mouse subdued to human idea and human use. So exactly is the Jax mouse, standardized as it is, and infinitely repeatable in its 7000 varieties. And just as Mickey Mouse became the iconic cartoon animal, so the Jax mouse established its species as the essential laboratory animal.

Both of these institutions, MRC Harwell and the Jackson Laboratory, belong to the International Mouse Phenotyping Consortium, an international collaboration whose aim is “to catalogue the functions of the roughly 20,000 genes that mice and humans share”. Last year the IMPC “released an analysis of the phenotypes of the first 1,751 new lines of unique “knockout mice” (mice in whom one gene has been deleted), with much more to come in the months ahead.” The National Institutes of Health, reporting this achievement, was especially interested in the genes which seem to have proven crucial to live birth in the mice. The heading to its announcement optimistically generalized the findings thus: ‘Of Mice and Men: Study Pinpoints Genes Essential for Life’.

Can mouse genetics really translate so usefully into knowledge about humans? In one of this month’s issues of the journal Science, there’s a report of research into “the nature of genetic predisposition to pain”, which is said to promise “new treatments of conditions affecting tens of millions of people worldwide”. Naturally the research used mice, designed and generated for the study (though using at least some Jax mice as starters). But other research in that same area of biology – incidentally an especially malignant one for laboratory animals, with its array of ingenious pain-supplying devices – has questioned the value of mice as models for humans, even where the same genes seem to be involved. An article about it in Yale Scientific said that “there was almost no correlation between human and murine reactions to any of the experimental conditions. For example, if humans were likely to activate a certain gene following trauma, mice were almost equally as likely to activate it or suppress it.” Acknowledging that “mice models are a cornerstone of biomedical research”, the Yale article suggests that this reported research “raises the question of how similar humans and mice really are. With such different genetic responses, perhaps the biology of mice is not an accurate representation of that of humans.”

Bad news in Bar Harbor and Harwell, then, but wait! A professor interviewed for the same article points out that the study only used the one mouse variety, C57BL/6, commonly called ‘Black 6’: “until other mouse strains are studied, the authors need to be cautious in their interpretations that use of mice is irrelevant to human responses.” Get out those order books, then, and let business resume.

The Yale article was headed ‘Of Mice and Men: The Mouse as a Model for Human Disease’. The upbeat NIH piece, you’ll recall, was headed ‘Of Mice and Men: Study Pinpoints Genes … etc.’ But it’s not much of a coincidence: that phrase, with its neat alliteration and reassuring link with a vaguely remembered literary classic, has also caught the imagination of many other science writers on this subject, or has at least appealed to them as likely to catch the imagination of their readers. After all, in a poll recently organised by an educational publisher, John Steinbeck’s fine novel Of Mice and Men has been ranked fourth in the “top 100 titles for the American literature classroom … chosen by American literature teachers across the country.” (But then The Great Gatsby came top!) And perhaps, although mice are only incidentally present in it, this story of two displaced and status-less labourers in forlorn search of a home is no bad fable for the modern animal.

But in fact the novel’s title is not the origin of the phrase. Steinbeck himself was borrowing it in his turn from the poem ‘To a mouse’ by Robert Burns, first published in 1786. And this certainly is an encounter of mouse and man to set beside and re-appraise the modern Disneyfied mass-mouse and the people who convert it into science.

The poem’s sub-title is ‘on turning her up in her nest with the plough’, for Burns was a farmer when he wrote the poem; he knew the situation. He was, besides, as the poem 220px-PG_1063Burns_Naysmithmakes poignantly clear, unhappy in his own ways, remorseful about the past and fearful as to the future. Accordingly there’s absolutely nothing suggestive of species-superiority in the way he speaks to the mouse, as he contemplates the ruin of her nest. He sees in detail and feels the catastrophe which the mouse has suffered, and he understands suffering as a universal burden, indifferent to species and size. Hence that phrase:

The best-laid schemes o’ mice an’ men
Gang aft agley,       

An’ lea’e us nought but grief an’ pain,
For promised joy!

The poem recognizes the encounter as an aspect of the power-relation whose characteristic modern manifestation we’ve been viewing in earlier paragraphs:

I’m truly sorry man’s dominion,
Has broken nature’s social union,
An’ justifies that ill opinion,
Which makes thee startle
At me, thy poor, earth-born companion
An’ fellow-mortal!

So the spoiling of the mouse’s nest is an incident in a much larger wreckage of that commonalty which Burns beautifully dignifies as “nature’s social union”. But in his poem he reasserts the union, at least between these two now present, pledging a true existential comradeship in those phrases “thy poor, earth-born companion / An’ fellow-mortal”.

And of course exactly this is “how similar humans and mice really are” (the phrase from the Yale article). They really are earth-born fellow-mortals, each in their own sphere liable to “grief an’ pain”. Unfortunately we’ve repudiated that fellowship for which Burns’s poem is a permanent model and recommendation, and have chosen instead to privilege human grief and pain, and to make of the mouse a multitudinous enslaved resource in our ruthless struggles to escape them.

 

 

Notes and references:

The numbers from 1875 were published by the Cardwell Commission in Report of the Royal Commission on the Practice of Subjecting Live Animals to Experiments for Scientific Purposes, HMSO, 1876, Appendix III.

Information and quotation about the work at Harwell appears on its web-site at https://www.har.mrc.ac.uk/

A clear, though highly technical, illustrated account of how a standard procedure works can be found in the article ‘Pronuclear Injection for the Production of Transgenic Mice’ at http://www.nature.com/nprot/journal/v2/n5/full/nprot.2007.145.html

About the welfare provisions in the U.S.A.: the “quirk” reference is from https://www.nap.edu/read/10733/chapter/11; the account of Helms’s amendment is from a contemporary news report in U.S.A. Today, readable at http://usatoday30.usatoday.com/news/nation/2002/05/07/animal-welfare.htm

What Clarence Little said about Mickey Mouse is quoted by Karen Rayder in Making Mice: Standardizing Animals for American Biomedical Research, 1900-1955, Princeton University Press, 2004, p.5

The announcement about the work of the IMPC is on a blog run by the National Institutes of Health at https://directorsblog.nih.gov/2016/09/20/of-mice-and-men-study-pinpoints-genes-essential-for-life/

The article in Science is from 16 June 2017, pp.1124-5 and 1168-71, quotations from pp.1124-5. The Yale Scientific article is from 5 April 2013, and can be read at http://www.yalescientific.org/2013/04/of-mice-and-men-the-mouse-as-a-model-for-human-disease/

The poll of American novels was organised by Perfection Learning, and is reported on their web-site at https://www.perfectionlearning.com/top-100-american-literature-titles.

The picture of Mickey Mouse is from the TV series Disney’s House of Mouse (2001-3). The portrait of Robert Burns in 1787 is by Alexander Naysmith, and is held in the collection of the Scottish National Portrait Gallery.

In the U.K., Animal Aid has recently started a campaign to raise awareness of the mouse, its qualities in nature, and its sufferings in laboratories: see https://www.animalaid.org.uk/animal-aid-new-campaign-mice-matter/

 

 

Thinking Ourselves Kings

In Frans de Waal’s most recent book about animal cognition – Are We Smart Enough to Know How Smart Animals Are? (2016) – he introduces to a general public many animal talents and capacities hitherto supposed unique to humans. His own specialism being primatology, he talks particularly about the social and political acumen of chimpanzees, forward planning among bonobos, reciprocal favours between capuchin monkeys, gorillas using tools, and so on. But he discusses also the skills of birds, cetaceans, octopuses, and many others.

The research which has revealed these accomplishments has often been picked up in media stories of the ‘smarter than we thought!’ genre. It’s a pity that the word ‘smart’, which in American English means simply ‘bright’ or ‘intelligent’, has in British English a suggestion of showiness or sophistication about it. For de Waal’s essential argument is that these various species have exactly the sort of intelligence which their situation in nature demands – intelligence developed for and within that situation, in fact. That’s what is implied in the term which he prefers for his branch of biology: evolutionary cognition. De Waal’s account of the ‘Kluger Hans’ story makes the point very well. Hans was famous in the early 20th century as a horse that could do sums, until a psychologist called Oskar Pfungst studied the performance and found that Hans was getting his cues for the answers from his unwitting trainer. The showy maths meant nothing to Hans, but understanding the body language of his trainer was a vital skill in which he had surpassed both his trainer and all their audiences.

The study which Pfungst then published did much to improve the techniques of experimental psychology. However, the Hans story was commonly understood as a caution against anthropomorphism, and therefore had the effect also, so de Waal says, of sanctioning a more sceptical and reductivist account of animal intelligence. At any rate there did follow what he calls the “this bleak period” for most of the 20th century, when (with the notable exception of Konrad Lorenz and his school of ethologists) the idea of intelligence or emotion in animals was dismissed as unscientific romance. In its place came the animal as mechanism: “the two dominant schools of thought viewed animals as either stimulus-response machines out to obtain rewards and avoid punishment or as robots genetically endowed with useful instincts.” [4]

But in the case of behaviourism – the stimulus-response school led by B.F.Skinner – at least the reductivism went right to the top: the pigeons learning their behaviour from the rewards and punishments administered in the ‘Skinner box’ were the models, however inadequate, for all animal mind, including the human. Hence Skinner’s foray into human politics in his books Walden Two (1948) and Beyond Freedom and Dignity (1971). He did not believe that humans were a special case, but applied to them the lessons he believed that he’d learnt from his animals. Here, at least, was impartial science.

But as de Waal shows again and again, studies in animal cognition have habitually been quite unscientifically partisan. Humans have been taken as the standard, and the intelligence of other animals has been judged according as they clumsily approximate to it. (One of de Waal’s chapters is titled ‘The Measure of All Things’.) The whole Nim project, for instance (as recounted in this blog for 8 May 2017), was essentially anthropocentric in this way: it asked how like a human a chimpanzee could be induced to behave.

De Waal shows that the very methodology of many studies has been carelessly biased.de Wall 2 Apes in sterile environments, behind bars or wire, take tests devised and presented by a different species (humans), and the results are compared to those achieved by human children in supportive human settings: the miserable contrast is well pictured in one of de Waal’s own illustrations. Earlier in the book he has aptly quoted the physicist Werner Heisenberg: “What we observe is not nature itself, but nature exposed to our method of questioning.” [7]

“What a bizarre animal we are,” de Waal exclaims, “that the only question we can ask in relation to our place in nature is Mirror, mirror on the wall, who is the smartest of them all?[157] It’s a well-chosen image, because the mirror test for self-awareness is an especially plain instance of the exam-bound mentality behind much comparative psychology. At this point we need to recall that nearly every research scientist is the triumphant product of almost two decades of successful test-taking. How could a mind be unaffected by this habituation? (Jane Goodall said in a recent BBC interview that she thought herself fortunate to have delayed formal scientific study until her late twenties. She never did study for an undergraduate degree.) Accordingly a conference report in Science, the journal of the American Association for the Advancement of Science, says, “Dolphins, it turns out, are pretty darn smart. Panelist Lori Marino, an expert on cetacean neuroanatomy at Emory University in Atlanta [incidentally, the same university in which de Waal is a professor of psychology] said they may be Earth’s second smartest creature, after humans, of course.” For instance, “They can recognise themselves in a mirror (a feat most animals fail at).” Fail! One wonders how such animals get on in later life. Nature, it seems, is seated at a giant exam, where the top mark is reserved for the examiners’ own relations (for of course that question we put to the mirror on the wall is a confidently rhetorical one: we know who).

De Waal is keenly alert to all the manifestations of this attitude. He speaks, for instance, of a research project in which sheep were shown to recognise and remember the pictured faces of other sheep (touchingly, “they actually called out to these pictures as if the individuals were present”). But he balks at the sub-title given to the published report, ‘sheep are not so stupid after all’: it’s “a title to which I object, since I don’t believe in stupid animals.” [72] Later he writes of the “patience and restraint” shown by apes and others, as much in the wild as in domestication: “self-control is an age-old feature of animal societies.” [221] And yet it’s often said of humans who fail to show these qualities that they’re behaving ‘like animals’. De Waal illustrates our senseless prejudice in this respect with a story told by the zoologist Desmond Morris. In the days when London Zoo (where Morris then worked) held chimpanzee tea parties, these apes, being quite capable of using tools, became too orderly and polished in their manners to please the public: in order to conform to expectations, they had to be trained to misbehave. The point is that science, supposedly the home of positivism, has been prejudiced in the same way. Summarising this whole comparative or rather competitive tradition in cognitive science, de Waal says with characteristic decisiveness, “I cannot think of a single profound insight it has yielded.” [12]

Happily, evolutionary cognition is now a well-established and rapidly growing discipline in science, with a large body of authoritative research already to its credit. Much of the success has no doubt been due to de Waal himself. Nowadays, who would think of saying, as a popular introduction did in the 1960s, that “there is essentially only one basic scientific interest in the study of animal behaviour, and that is to learn more about man himself”? However, the subject still does face resistance; in particular its egalitarian premise does. I don’t mean the sort of particular challenges which all science needs in order to remain healthy, but something more like an ideological antagonism.

A recent book title (cited by de Waal) makes the point: The Gap: The Science of What Separates Us from Other Animals (2013). But at least here we are pictured in the same kingdom as our evolutionary fellow-products, the ‘other animals’. The more absolute case has been summarised in the ugly coinage ‘humaniqueness’, a word aimed at fixing into being this strange intellectual hybrid of science and ideology. The case was put in the 2008 Tanner Lectures on Human Values at Princeton University, titled ‘The Seeds of Humanity’ and delivered by the man who coined that absurd term. The two lectures by Marc Hauser, then a professor of pscyhology and human evolutionary biology at Harvard University, are densely argued texts, but their ideological theme is clearly established in the introductory paragraphs. Here is a taste of it, starting with the first sentence of all:

Humans create plays, operas, sculptures, computers, equations, laws, religions, guns, and soufflés. This is only a partial list of our achievements. In the history of life on earth, we are the only species to have created such creations … These observations suggest the first radical proposition I will make: we are not animals … If the fact that we share some 98 per cent of our genes with chimpanzees is meaningful, then why isn’t a chimpanzee writing this essay, or singing backup for the Rolling Stones, or working on quantum computing, or adjudicating over a legal case, or making me a soufflé? … Looked at in this way, a chimpanzee is a chimpanzee is a chimpanzee – a cultural non-starter.

This is the prospectus, familiarly bumptious in its formulation, for the extreme form of what de Waal calls “an us-versus-them world”. That’s indeed the world which has been made for us in the West over the centuries, and which has been costing “them” ever more and more in pains and lives. And there’s surely still a persuasible audience for such thinking as this, even or perhaps especially among scientists, for it leaves us with nothing to apologise for or, more crucially, to change our ways for, and of course it makes us proud to be human.

De Waal’s book is a detailed critique of the ‘humaniqueness’ outlook. It is part of his own case that apes do indeed have cultures and other “creative” accomplishments, but that these are themselves prompts toward farther (not lower, but less immediately accessible) reaches of intelligence among animals more distant from humans in the evolutionary complex:

After the apes break down the dam between humans and the rest of the animal kingdom, the floodgates often open to include species after species. Cognitive ripples spread from apes to monkeys to dolphins, elephants, and dogs, followed by birds, reptiles, fish, and sometimes invertebrates … an ever-expanding pool of possibilities in which the cognition of, say, the octopus may be no less astonishing than that of any given mammal or bird. [69-70]

So what are we: a lonely self-congratulating elite, scorning and battening upon the rest of nature, or fellow-swimmers in the waters of cognition? It’s a choice not just for cognitive science, but also for the moral and spiritual faculties which Hauser thinks so well of humans for having. I shall end with one tragi-comic utterance on the question Rouaultfrom those latter regions of the human mind, by the great French artist Georges Rouault: the print titled Nous nous croyons rois (‘We think ourselves kings’). It was made during the First World War. Its eloquence makes further comment superfluous.

 

 

 

 

 

 

Notes and references:

Are We Smart Enough to Know How Smart Animals Are? (2016) is published in the UK by Granta Books, and in the USA by Norton and Co. The Desmond Morris story appears on p.223, and is referenced to R. and D. Morris, Men and Apes, McGraw-Hill, 1966. Page numbers for quotations are given in the brackets.

Jane Goodall was being interviewed on BBC Radio 3 on Sunday 14 May for the programme Private Passions.

The popular introduction from the 1960s is P. L. Broadhurst’s The Science of Animal Behaviour, Penguin Books, 1963: quotation from p.12. There is more about this book and its times in the post for 10 October 2016.

The conference report in Science (an excellent journal) appears in the issue for 26 February 2010.

The 2008 Tanner Lectures can be read at http://tannerlectures.utah.edu/_documents/a-to-z/h/Hauser_08.pdf

Georges Rouault’s Nous nous croyons rois is number 7 in his print series entitled Miserere, first published in part in 1927, and published complete as Miserere et Guerre in 1948. Unfortunately I can’t recall where I have the image from, but I hope the source will forgive its use here.

 

Starvation Street

As one considers the wonderful diversity of animal life – my Standard Natural History speaks of “an almost awe-inspiring variety of form and size and coloration” – one naturally asks how long it takes all of these different animals to die of hunger. Happily, physiologists have been gathering experimental answers to this question for some 150 years. To start at the smaller end of things, for instance, hawk moth larvae (Manduca sexta) tend to die after 3 days without food, the house cricket (Achetes domesticus) after 5 days, and the Madagascar hissing cockroach (Gromphadorhina portentosa) after 52 days. These numbers, I should say, are measures of LT50: that is, the “lethal time” at which 50% of the individuals participating in the experiment are dead. Not that LT50 simply increases with size. Among bumble bees (Bombus impatiens), for instance, the smaller nursing bees apparently last longer than their larger foraging sisters.

Of course there is still a great deal to learn. Even the modest puzzle thrown up by the differential death-rates of those 1,432 bees that starved in the last-mentioned experiment shows that “there is a need for additional comparative studies of starvation physiology among many key groups of vertebrates and insects”. The trouble is, as the author of the multi-insect study says, there are “ethical concerns” associated with “starving vertebrate animals to death”. In general, therefore, the experiments have to be based on “sub-lethal periods of fasting”. His own study of various snakes, for instance (vipers, boa constrictors, pythons, rattlesnakes and others, a hundred in all), had them fasting for “sub-lethal periods” of 56, 112, and 168 days. Not that they survived the research – as we know, almost no animals in laboratories do – but they didn’t suffer what the author calls “starvation-induced mortality”. They died in some more “ethical” way.

The limitations imposed on research nowadays by these scruples may partly explain why the less inhibited work done in this subject a long time ago is still regularly cited: for instance, the pioneering work of Charles Chossat (published in 1843 as Recherches expérimentales sur l’inanition). Those, after all, were the days when it could safely be assumed that “no student of science would, as a student of science, do that which was not worthy of him”: so said Sir William Gull, physician to Queen Victoria, adding that cruelty laws were “made for the ignorant, and not for the best people in the country”. If a scientist was doing it, it was ipso facto ethical. And besides, as another waiting for the endmedical scientist of the period said, being starved by Chossat or by any other agency involved “very little suffering”. (Being frozen to death was even better – “the reverse of painful”, he said – so that’s evidently the way to go.)

Generations of cats, dogs, rabbits, mice, pigeons, frogs, and others went on testing this claim, and their miserable experiences are still drawn on in modern studies, now that some better reason than merely finding things out has to be produced to justify “total fasting”, at least for the larger animals. Not that such reasons can’t readily be found or at least evoked: I note, for instance, a 1975 paper on the differential fasting to death of fat and thin mice, which modestly but crucially claims for itself “the potential of applicability of [these] findings to man”.  

But it’s doubtful whether the starving of other animals has ever been of very significant ‘applicability to man’. After all, this is a branch of medical science in which there has always been plentiful human data available. Another classic of the subject, Francis Benedict’s A Study of Prolonged Fasting (1915), follows one human volunteer through a 31-day fast in minutest detail for over 400 pages. The clarity of its analysis is, of course, greatly assisted by the voluble co-operation of the volunteer. In fact the book, though replete with measurements of various kinds, reads at times like a novel, the starver himself being a distinct individual (as indeed all animals necessarily are, whether we happen to notice it or not).

In Benedict’s time, fasting was even being practised as a form of entertainment. One of the short stories of Franz Kafka describes the experiences of one such ‘hunger artist’ (‘Ein Hungerkünstler’, 1922). The most famous of these practitioners was Giovanni Succi, whom Benedict had actually considered employing (but he cost too much). Although, in his capacity as a research subject, Succi was primarily the property of a Florentine scientist, Professor Luigi Luciani, he performed internationally, and during a fast in London, so the Times reported in 1890, “he has been visited by many gentlemen of the Succimedical profession, by whom his feat is regarded with much interest … important physiological deductions may be made from the experiment.” (The illustration shows Succi being visited by scientists during an earlier American tour.)

Another performer at the same London venue (the Westminster Aquarium) was called ‘Monsieur Jaques’, and he brought along his own applied research in the form of a herbal powder. This powder, he claimed, even in tiny quantities could on its own sustain life, and had indeed done so at the town of Belfort while it was besieged during the Franco-Prussian War of 1870-1. If there was some charlatanism mixed up in all this, then it was the business of physiologists to separate the science from the show business (as indeed some of them did), for there was knowledge to be found here of much more immediate importance “to man” than could be supplied by making pigeons or rabbits starve.

Fasting as a performance has long since gone out of fashion (though there was a reprise of sorts by the magician David Blaine in 2003). But human starvation, endured purposefully or not, has continued to provide its own data. Death by starvation in the U.K. usually entails an inquest and post-mortem: invariably so if it happens in prison – through hunger strike, in other words. There must therefore exist very many records of this sort. I notice a United Nations University report on starvation from the 1990s which makes use of just this sort of data, including information about hunger strikes of prisoners in Northern Ireland in the 1980s. Such a report to the U.N. would necessarily be aiming to provide thoroughly usable conclusions. (Even here, Chossat and his disciples put in an appearance, with their species mortality lists, as some sort of comparative back-up to the human material.)

However, starvation research of the kind instanced at the start of this piece has very little reference to medical usefulness: it’s a branch of zoology, a contribution to our knowledge of nature, answering the question I started with. Conditional on the ethical restraints mentioned, it’s free to grow as it will, and it does indeed demonstrate how growth works in such academic subjects. Each study raises new questions and calls for further research. Revisions, polite controversies, and synoptic reviews accumulate (already in 2010, a review of starvation studies had hundreds of papers to encompass). In time the subject becomes a sort of profession in itself, with its own conferences, authorities, jargon, journals, and honoured history (enter Chossat again). For you’ve scarcely broken ground when you simply starve a Madagascar hissing cockroach or a rattlesnake: you must go on to complicate the scene with other types of stress, add or withhold water, make the fast sustained or intermittent, start with fat or thin subjects or both (we’ve already noticed that). As a witness before a House of Representatives committee on vivisection once remarked, “you’d be surprised what professors and some students can think up”.

But a hawk moth larva, at least, or a house cricket, these don’t feel pain? Lest the question itself should sound like an invitation to fascinating new research, I shall put it another way: do they mind starving? To this we already have the answer because, as experimenters in starvation know well, precautions have to be taken against cheating, even among such innocents: they’ll eat their own excrement, or bedding, or each other, rather than starve honourably in the cause. So yes, even these have the urge to go on living, as we do, as all animal life does.

When a scientist alludes to “the ethical concerns of starving vertebrate animals to death”, he makes even morality sound like a technical matter, another aspect of the laboratory scene, something checked by glancing over one’s shoulder. No doubt it usually is just that, but it ought rather to be part of his or her own mentality. It would be much more convincing if the scientist said “we wouldn’t want to do that.” They might then set themselves to thinking up ways of studying life which don’t involve destroying its denizens, even these slightest of them. That would begin to answer Tony Benn’s question “Where is your moral teaching in science?” [see blog for 21 November, 2016] Meanwhile the moral teaching, the ethical motive, have to be urged upon the life sciences in the way they always have been over the last 150 years: that is, from outside. And in this particular case, one small thing which can be done now is to sign the following petition remonstrating against the starvation studies presently conducted at St Mary’s University of San Antonio in Texas: https://www.peta.org/action/action-alerts/rats-starvation-experiment-st-marys-university/?utm_campaign=051217%20peta%20e-news&utm_source=peta%20e-mail&utm_medium=e-news

Notes and references:

The insect study: Marshall D. McCue et al, ‘How and why do insects rely on endogenous protein and lipid resources during lethal bouts of starvation? A new application for C-breath testing’, PLoS One, 2015, 10(10). The bumble-bee study: M.J.Couvillon and A.Dornhaus, ‘Small worker bumble bees (Bombus impatiens) are hardier against starvation than their larger sisters’, Insectes Soc., May 2010, 57(2). The snake study: Marshall D. McCue, ‘Fatty acid analyses may provide insight into the progression of starvation among squamate reptiles’, Comparative Biochemistry and Physiology A: Molecular and Integrative Physiology, Oct. 2008, 151(2) The mouse study: G.S.Cuendet et al, ‘Hormone-substrate responses to total fasting in lean and obese mice’, American Journal of Physiology, Jan.1975, 228(1). The 2010 review: Marshall D. McCue, ‘Starvation physiology: reviewing the different strategies animals use to survive a common challenge’, Comparative Biochemistry and Physiology A: Molecular and Integrative Physiology, May 2010, 156(1)

Sir William Gull and Dr Francis Sibson are quoted from their evidence to the Cardwell Commission in 1876: Report of the Royal Commission on the Practice of Subjecting Live Animals to Experiments for Scientific Purposes, HMSO, 1876, pp.265-7, and 237.

Quotation and other details about the hunger artists are taken from reports in the London Times on 24 March, 12 April, and 23 June 1890.

The UN report: M.Elia, ‘Effect of starvation and very low calorie diets on protein-energy relationships in lean and obese subjects’, published in Protein-Energy Interactions, ed. Scrimshaw and Schürch, 1992, accessible online at http://archive.unu.edu/unupress/food2/UID07E/UID07E11.HTM

The evidence to the House of Representatives committee investigating the treatment of animals used in research, 1962, is quoted by John Vyvyan in The Dark Face of Science, London (Michael Joseph), 1971, p.188.

The two wood-engravings: ‘Waiting for Death’ (1832), by Thomas Bewick, shows a horse at the end of its career of usefulness to humans, turned out, as Bewick notes, “to starve of hunger and of cold”; the picture of Succi and medical company is from the Christian Herald (New York 1886), courtesy of Internet Archive.

The Antiviv: a Hospital without Cruelty

At a biomedical research establishment in Holland shown in the BBC documentary Monkey Lab (BBC3, April 17), a veterinary assistant speaks of her affection for the animals which are used in experiments there:  “Sometimes I really have to cry a little bit … So why do I have this job?” The answer she gives is that she herself uses medicines, and to shun the work which provides them would make her “a hypocrite”.

In one form or another it’s an argument which is frequently used against those who object to vivisection. Someone prepared to benefit from the therapies which medical science produces cannot honourably object to the means used to produce them; or to put it the other way round, anyone who does object to vivisection should refuse its products. And just so that we should know what that implies, the champions of vivisection would like these products to advertise their origins in animal research: “there is a case”, said Lord Winston in a House of Lords debate, “for having legislation to make it clear that a particular drug has only been possible for human consumption because of animal testing. This could be stamped on the packet, rather like a cigarette packet.” This drug, in short, will defeat your ethics. Lord Taverne developed the idea: “it would be beneficial if every general practice surgery displayed a notice stating ‘All the drugs used or recommended in this surgery have been tested on animals.’ ” Merely by consulting a doctor, then, someone opposed to vivisection is discrediting their principles. The aim is to freeze such people out of the health service, or rather, since they have to be a part of it, if only by paying taxes, to freeze out their ethics.

As a matter of fact, living up to their ideals is something that few humans do manage, and I can’t see that the merit of the ideals is compromised by that. As Robert Browning’s artist Andrea del Sarto says, “a man’s reach should exceed his grasp, / Or what’s Heaven for?” If we don’t aim higher than we can presently get, ethics would become merely a matter of describing how we do behave, not how we ought to. Of course, a campaigner against animal abuse who isn’t vegan is plainly contradicting themselves. But then there’s a real alternative choice there – not to eat animal products – and it’s a choice which anyone can easily make. There is no such choice in modern medicine, here in Britain at least and probably anywhere. The nation has only one health service, it’s supported involuntarily by all who pay taxes, and it’s premised on animal research.

In that sense, medicine is a service like policing, fire-fighting, or defence: you pay for it, and you get it in the one available form, whether you like that or not. If you don’t like it, you must hope and try to have it changed. Meanwhile, you may heroically shun it altogether, or at least use it as little and as judiciously as possible. But it’s as unreasonable to argue that someone who objects to animal research ought to do without the state’s medical assistance as to say that someone who campaigns for changes in the police or fire services should do without police protection or should make their own arrangements about putting their house out if it catches fire.

In fact even before the National Health Service was established in 1948, the medical profession had made animal research an inseparable part of its institutions. This is what made the controversy in Oxford in the mid-1880s so crucial. By building and endowing an animal research laboratory, to the specifications and for the use of one of the nation’s leading practitioners of vivisection (Professor Burdon Sanderson), the University was endorsing and confirming the practice as the way into the profession for its students. Prophetically, then, the man who led the opposition to this development in the University, Bodley’s Librarian E.W.B.Nicholson, warned his colleagues, as the date for the final vote on the subject approached, “If we are beaten then, we are beaten for ever.” To teach medicine as an animal-using discipline was to fix it as such for all subsequent generations of practitioners.

Here’s an illustration of how that works, from ten years previously:

Lord Cardwell (taking evidence during the 1876 Royal Commission on animals in science): Therefore any students who come there, so far as your teaching and influence are concerned, adopt, I presume, the principle that you have adopted?

Dr Klein (professor of pathology at the Brown Institute, London): Yes.

Lord Cardwell: And consider that a physiological inquirer has too much to do to think about the sufferings of the animals.

Dr Klein: Yes.

Even so, attempts have been made to break this monopoly of the vivisectors in medicine, and to provide a cruelty-free alternative. One such was the National Anti-Vivisection Hospital, established at Battersea Park, London, not far from the scene of the 1907 Brown Dog riots (see the post for 7 August 2015). In fact the hospital was itself briefly caught up in those riots when a band of medical students, driven away from the Brown Dog statue itself, made the nearby building its target. Their indignation and violence (more deliberate and destructive, incidentally, than anything that animal rights “extremists” have ever done) reflected a medical training which now committed them in practice and professional allegiance to experimentation on animals. That is, they saw anti-vivisection as a threat, or at least an insult, to their craft, prestige, and livelihood. Fortunately the hospital, like the statue, was adequately defended on that occasion, mainly by the local population.

Here are a few facts about Battersea’s National Antivivisection Hospital, also known as ‘the Antiviv’. It opened in 1903 at Lock’s Folly, 33 Prince of Wales Drive. The money for it had been raised by the National Anti-Vivisection Society, and it was subsequently kept going and expanding largely by donations and bequests from well-off sympathizers. It was located in a poor district of London, to whose people it provided a precious service (doing “great and useful work”, according to Battersea’s mayor in 1907), and these people too supported it, not only by strength of arm as mentioned, but also by fund-raising: carnivals, concerts, boxing tournaments, more poignantly by direct gifts, including free work. By the end of the 1920s, the hospital was treating 400 in-patients and 40,000 out-patients each year.

During all this time the hospital was, in the words of its own board of directors, “a standing protest against cruel experiments on animals, and a concrete demonstration that these are not necessary for the succour of the maimed or the healing of the sick.” Nor was this “protest” merely implicit: there was a notice-board outside which declared the hospital’s principles. The principles were that no experimentation on animals or humans (this last a common and not unfounded fear among working people at the time) would occur on its premises, by way of training or research; there would be no treatments derived from live animals; and its staff would all have signed a declaration against vivisection. It was the opposite, then, of the doctor’s surgery as proposed by Lord Taverne.

Of course the Antiviv had difficulty paying its way. This was a difficulty for all the ‘voluntary’ hospitals (meaning those not owned and funded by local authorities or the state, i.e. most of them). It was exactly in acknowledgement of this general problem that the Prince of Wales ‘s (later King Edward’s) Hospital Fund for London had been set up in 1897. Through this agency, funds were to be raised in a systematic way and distributed to the voluntary hospitals – those of them, at least, which were assessed as efficiently run. Naturally the Battersea Hospital frequently applied for funds from this source, but although the Fund never seems to have found fault with the running of the hospital, it consistently withheld its support. The Fund’s reasoning was variously expressed at different times and by different individuals, but the essential reason was clear: its General Council did not wish to encourage a venture which, as one hospital fund-raiser put it, “casts a great slur upon the profession generally”. Sir Henry Burdett, a leading member of the Council, argued that an anti-vivisection hospital was impossible anyway, because there was no modern medicine or medical treatment which had not at some point involved animal research. To take a stand against it was therefore “humbug”.  Already in 1909, then, the hypocrisy charge was being used to discredit and subvert any effort to make medicine cruelty-free.

The Antiviv closed down in 1935. Its last chair of the board of governors, Lord Ernest Hamilton, blamed the failure on “this ceaseless hostility of King Edward’s Hospital Fund administrators who refused to help us. If they had helped us, we should now be financially solvent, but they have refused to give us a penny.” (It’s an unhappy irony that the Fund had been set up in the first place “to commemorate the 60th anniversary of the Queen’s reign” – in tribute, that is, to a monarch who was passionately opposed to what she called “this horrible, brutalising, unchristian-like vivisection … a disgrace to a civilized country”.) That the Antiviv had been working well as a hospital is sufficiently indicated by the fact that, having simply changed its name to the Battersea General Hospital and dropped its anti-vivisection rules, it continued to function as before, in fact went on serving South London until 1972. The building was demolished in 1974, and its address no longer exists: a huge block of modernistic flats now squats on the historied site.

The Antiviv was not the only attempt to set up a cruelty-free health service, but it was the latest to survive. What Burdett said about it, that it couldn’t actually free itself of the products of animal research, was probably true. In fact, that was always a controversial question among its own people, how strict to try to be. In this matter, there can be no innocence any more, and already there could not be then: the medical profession itself had made sure of it. But the “reach” was absolutely right, towards a health service in which the great talents, skills, and practical compassion of the professionals would not be dishonoured by a background in animal exploitation. That the “grasp” failed, for that time, was a tragedy – one that, as we’ve seen, need not have happened. It says nothing about the validity of the ambition, only about the wretched history of its deliberate defeat, that those who champion it are still obliged, if they’re to accept scientific help in time of need, to participate in that dishonour.

 

 

Notes and references:

The Lords Winston and Taverne were speaking in the House of Lords debate on the transposition of EU Directive 2010/63 on 31 October, 2011. The subject was debated again in similar terms in that House on 25 October, 2013, with reference to the Medicinal Labelling Bill.

E.W.B.Nicholson’s words come from a letter which he sent to all signatories to the Oxford campaign on 6 March, 1885 (Bodleian Library 1516d.4).

The Cardwell/Klein exchange is from Report of the Royal Commission on the Practice of Subjecting Live Animals to Experiments for Scientific Purposes, HMSO, 1876, p.185.

Information and quotations about the Battersea Hospital come mainly from ‘Boycotted Hospital: The National Anti-Vivisection Hospital, London, 1903-1935’, A.W.H.Bates, Journal of Animal Ethics, vol.6, no.2 (Fall 2016), pp.177-87; also from Coral Lansbury, The Old Brown Dog: Women, Workers, and Vivisection in Edwardian England, University of Wisconsin Press, 1985, especially chapter 1 (the “great slur” quotation is from p.19); and from reports in the Times newspaper for 1 October, 1907, and 31 May, 1935 (on the maintenance and then closure of the hospital), and 6 February, 1897 (on the founding of the Prince of Wales’s Hospital Fund).

The words of Queen Victoria are taken from letters written to the Prime Minister William Gladstone and the Home Secretary William Harcourt in the early 1880s (see The Extended Circle, ed. Jon Wynne-Tyson, 1985, p.386).

Nim: the Life of a Chimpanzee

Among the various attempts to persuade chimpanzees or other great apes to use a human language, the most famous or notorious, certainly the most written-about, has been ‘Project Nim’ – the attempt, from 1973 to 1977, by Herbert Terrace at the University of Columbia, to teach the animal whom he originally named Neam Chimpsky to use American Sign Language (ASL).

That name itself was ominous. True, it wasn’t a senseless joke. Terrace, a behavioural psychologist, wished to test Noam Chomsky’s claim that language, as humans used it, was a unique and innate capacity of the human brain. If a chimpanzee, brought up in human society, could learn to converse in some way with humans, that much language at least would be shown to be the product of culture, a learned behaviour. So Terrace named the chimpanzee to show that the project was a challenge to Noam Chomsky. But unfortunately the name also expresses an estimate of value. Like the name ‘Dolly’ for the cloned sheep (see the VERO blog on 29 August, 2016), it makes a joke of the animal’s participation in human affairs. In fact it belongs with the mock-dignity of a chimpanzees’ tea-party. An animal not to be much respected in itself, then, but made over to a human purpose: that was the implication of the name.

Accordingly, it was Neam Chimpsky’s fate to be snatched with unceremonious violence from his captive mother (a ‘breeding’ chimpanzee at Dr William Lemmon’s Institute for Primate Studies in Oklahoma), pitched into a more or less unprepared human family in New York, and wholly subject for the next four years to the chaotic professional and private interests of whatever people Terrace could find to run the Nim_Chimpskychimpanzee’s education and home life. Most of those people proved devoted and loyal to Nim (as he came to be called) while they stayed with him. It was not so much the difficulties of looking after Nim, though these were great enough, as the instability of the human relationships that caused what Terrace himself calls “the necessity of introducing more and more teachers into his life … The revolving-door manner in which caretakers cycled through Project Nim”. Nim’s so-called “socialization” in fact consisted in a succession of broken homes: a training in delinquency.

Yet during this time Nim rose above his slighting name and its moral implications, and re-characterized it in his own true image, as vital things do (poor Dolly was too unassertive to discredit the joky etymology of her name, as it deserved). The ‘Chimpsky’ disappeared from ordinary use, and the ‘Noam’ reference was forgotten. In fact, discovering Nim as a real and enduring being is the most interesting lesson that Herbert Terrace can be seen to learn during his own account of the project, the 1979 book Nim. Accustomed to pigeons and rats as subjects, creatures which he could with impunity put away in cages and forget when not in use, he found that Nim was a 24-hour phenomenon: “Even more than a human infant [of which Terrace had no experience either], Nim needed constant contact and attention.” More urgently, chimpanzees mature quickly, so that any “unseized opportunity to teach Nim to sign seemed to be an opportunity lost forever.” In practice, Terrace mostly delegated these demands, but even delegating them required time and understanding.

A theme for a comedy, perhaps: harassed scientist taught to live and love by warm-hearted monkey. But in fact the story of Nim was a tragedy. There came a time, unprepared-for like most of what happened during the project, when Nim’s growing strength started to make his vagarious moods a physical danger to his carers (there were several trips to hospital). Both man-hours and funds for the research were becoming scarce, and anyway Terrace now had plentiful results in notes and film of Nim’s communications during nearly four years on which to base his research conclusions. So Nim was indeed put back in his cage: that is, he was sedated, as his mother had been when he was stolen from her, and taken to the place which one writer about Nim (Elizabeth Hess) describes as “a dreary, crowded, woefully inadequate cement prison” – the Institute for Primate Studies from which he had come. Having been taught to regard himself as a human (when asked to sort photographs of chimpanzees and humans, he had put his own picture among the humans), he was thrown back among his own kind and left to start again.

Terrace himself, a more sympathetic man than Dr Lemmon, devoted a chapter of his book to this miserable event. The chapter is somewhat disingenuously titled ‘Nim Leaves’, but it doesn’t shirk the pain and violence involved. After all, such ASL as Nim had learned did not encompass explanations or persuasions. The parting had to be done with a trick:

Nim didn’t realize what had happened until I got up and padlocked the door. He then began to scream and tried to force the door open … Without further ceremony we all walked out of the building. I will never forget Nim’s incessant ear-piercing screams and his look of fear and anger when I abandoned him in his cage.

In the recent documentary film Project Nim (2011) one of Nim’s household who had been present on that occasion still seems tearful when she remembers it: “a nasty thing to do … We coaxed him down there because he trusted us … We did a huge disservice to that soul. And shame on us.”

But Terrace had in preparation what many of his co-adjutors regarded as a further betrayal, this one strictly as a scientist. In his report on the research published in the journal Science in 1979, he argued that Nim had not been using ASL as a proper language at all. Nim had learnt to use many individual word-signs (125 of them by the end), and could use them in combinations of up to four, but there was no good evidence that he was using a syntax to make variable sense of them, still less that he was generating altogether new meanings in such a way. Not just Nim, either. Terrace rejected also the more positive conclusions of previous studies (for instance, the work of Allen and Beatrix Gardner with the chimpanzee Washoe). The title of the article was ‘Can an Ape Create a Sentence?’ The answer which Terrace gave was this: “Apes can learn many isolated symbols (as can dogs, horses, and other non-human species), but they show no unequivocal evidence of mastering the conversational, semantic, or syntactic organization of language.” In short, no.

Terrace did not altogether abjure the romantic possibilities of inter-species communication which his own research seemed thus to have closed off. At the very end of his book, he writes that such communication would be “as exhilarating as receiving a message from outer space”, while to introduce language into the culture of a group of chimpanzees “might provide a priceless glimpse of what life was like at the dawn of human civilization.” But this may have been the licensed rhetoric of a book’s last lines. The question with which he starts the book, whether “humans could take comfort in the assurance that our language made us unique”, had been emphatically answered. Terrace told the New York Times, “Language still stands as an important definition of the human species.”

So it turns out that Nim was not teaching humans to understand a different animal; he was just helping us to take another admiring look at ourselves in the mirror: as Terrace more recently said of Nim, with familiar speciesist condescension, “he should be greatly respected for sharing himself and his abilities in the pursuit of what it means to be human.” No surprise that this last quotation comes from a piece published on a pro-vivisection web-site.

Terrace’s much-publicized conclusions from his research certainly had a baleful effect on other such projects and their chances of getting funds. We may not regret that in itself, but more importantly his conclusions have also helped to keep chimpanzees and the other great apes, and in a queue behind them all the other animals, for that much longer outside the circle of our moral fellowship. And thus a quarter of a century later Oxford’s Professor Colin Blakemore could still be defending the use of great apes in experiments on the grounds that “there is only one very secure definition that can be made, and that is between our species and others.” Nim’s return to prison was, in this sense, wholly emblematic.

As I said, there have been many tellings of the Nim story. The most thorough, apart Nim books copyfrom Terrace’s own account, would be Elizabeth Hess’s Nim Chimpsky: the Chimp who would be Human (2008), the book on which James Marsh’s film Project Nim was based. One of the briefest and most poignant versions was published in the New Yorker in 1976, while Nim was still in ‘education’ at Columbia. The author, Mark Helprin, doesn’t in fact mention Nim by name; it’s possible he had no knowledge of him (though Terrace was good at generating publicity for his research in the media). Rather, Helprin tells the larger story of which poor Nim’s career is an illustration. The title is ‘Letters from the Samantha’.

The captain of “an iron-hulled sailing ship” is reporting to his superiors a typhoon and its troublesome consequences. From that sudden violence in nature, the ship has come into possession of “a large monkey”. The presence of an animal on board is a serious breach of regulations, but unlike lesser creatures, which the captain has from time to time found on the ship and promptly dispatched, this one makes special claims, being “like a man”. Indeed, it was the captain himself who had him rescued. And once he has been fed, the monkey becomes biddable, even friendly. A special “throne” is made for him. But his presence produces disciplinary problems among the crew, and the captain feels that he’s losing his own authority on the ship. Still, he cannot bring himself to order the monkey to be thrown back into the sea: “I brought him on board in the first place.” More than that: the monkey’s personality has had a powerful effect upon the captain: so far from his dominating the animal, “it is I and not the monkey who have been converted, although to what I do not know.” But finally, disregarding the various opinions of his crew (just as Terrace suddenly announced to his staff the end of ‘Project Nim’), and more significantly violating what he himself has learnt, the captain grasps the monkey, subdues his struggles, and throws him overboard to drown. And now he must restore a proper attitude on board the ship. Accordingly, he addresses the crew on the subject of the ape thus:

He is not a symbol. He stands neither for innocence nor for evil. There is no parable and no lesson in his coming and going … He does not stand for a man or men. He stands for nothing. He was an ape, simian and lean, half sensible. He came on board, and now he is gone.

 

 

Notes and references:

The book written by Terrace himself is Nim: a Chimpanzee Who Learned Sign Language (Knopf 1979). Quotations are from the U.K. edition (Eyre Methuen, 1980) pp.97, 108, 5, 127, 202, 226-7, 4.

Quotations from Nim Chimpsky, the Chimp Who Would Be Human, by Elizabeth Hess (Bantam, 2008), are from the 2009 paperback edition, pp.46 and 242 (which quotes Terrace speaking to the New York Times).

‘Can an Ape Create a Sentence?’ appeared in Science, 23 November 1979, vol.206, no.4421, pp.891-902. The full authorship was H.S.Terrace, L.A.Petitto, R.J.Sanders, and T.G.Bever. The recent comment from Terrace (“… what it means to be human”) appeared on the website Speaking of Research, in a ‘guest’ post, 15 August 2011.

Colin Blakemore was quoted in the Independent, 2 June 2006, introducing a Medical Research Council publication which promoted the benefits of experimentation on non-human primates – including, when “necessary”, the great apes (chimpanzees, gorillas, orangutans, and bonobos).

Among other discussions of the Nim story, these two are especially interesting: (1) Peter Singer’s review of the film Project Nim, and the unfriendly exchange between Singer and Terrace which followed it, in the New York Review of Books for 13 October and 24 November 2011; (2) another review of the film, this one a really fine and impassioned piece of writing (it starts with an attack on the name Nim Chimpsky) in the journal Dissent, 17 August 2011, by Benjamin Hale. The Dissent article can be read here:  https://www.dissentmagazine.org/online_articles/the-sad-story-of-nim-chimpsky.

The short story ‘Letters from the Samantha’, by Mark Helprin, was first published in the New Yorker, 5 January 1976. It has been re-published in Helprin’s Ellis Island and Other Stories (Dell, 1981), and also in the excellent American Short Story Masterpieces, ed. Raymond Carver and Tom Jenks (Dell, 1987), pp.271-82.

The illustrations show Nim washing up, and two book covers: the front of Hess’s book, and the back cover of Terrace’s book Nim, picturing the author and the chimpanzee.

As to Nim’s later life: he stayed at the IPS until 1982, when it began to fail as a paying concern. He was then sold on to somewhere very much worse, New York University’s Laboratory for Experimental Medicine and Surgery in Primates, with its grotesquely inappropriate acronym LEMSIP. After a very public controversy, in which Terrace took a part arguing for special treatment in Nim’s case (other chimpanzees were sold to LEMSIP at the same time and stayed), Nim was taken back to the IPS. In 1983, Nim was sold again, this time to the Black Beauty Ranch in Texas, property of the animal activist Cleveland Amory. This was a wholly benevolent animal sanctuary, but it was primarily for equines, and for a year or so Nim lived a wretched life alone in a cage, a period vividly recorded in the film Project Nim. Then other chimpanzees were brought to Black Beauty, and we can hope that Nim lived a reasonably contented life until his premature death at 26 years of age in 2000.

 

 

 

Ecce Homo

Today, 24 April, is World Day for Animals in Laboratories. It’s impossible to know even approximately how many animals are making this claim on our attention, because most of them are unrecorded. Even where there are official counts, the rules and standards differ. The U.S.A., for instance, does not include in its published figures any rats, mice, birds, or frogs – the most commonly used lab animals. Its last official total (767,622 in 2015) is therefore likely to have been about 1% of the true number. The most recent attempt to produce a reasoned estimate of the world total (a 2014 report commissioned by Lush Cosmetics) put it at over 118 million, but conceded that this was itself very probably much less than the truth.

Here in the U.K., the main event to mark WDAIL will take place in Birmingham on Saturday 29 April. This is the link to the facebook page: https://www.facebook.com/events/440619619606340

At the head of that page, there is just the one pictured animal, the monkey as shown here, to represent those WDAIL monkeyuncounted millions, but it’s the right one, as I shall say later. On Easter week-end, which is when I am writing this, the hideous contraption (I don’t know its technical name) which has been clamped to the monkey’s head appears like a stylized crown of thorns.

MantegnaThere’s unfortunately nothing far-fetched about such a comparison. In fact it was put to the congregation of the Oxford University Church long ago by one of the University’s most eloquent preachers and noblest men, John Henry Newman. At that time (early 1840s), he was vicar of that church and parish, as well as a university tutor. He was giving the Easter sermon, and he wished to persuade that congregation, largely consisting as it did (or so he was increasingly coming to feel) of over-comfortable and under-spiritual colleagues, to have a more living sense of “those awful sufferings whereby our salvation has been purchased”. He hoped to do this by inviting his listeners to recollect “how very horrible it is to read the accounts which sometimes meet us of cruelties exercised on brute animals”, and in particular those cruelties which were “the cold-blooded and calculating act of men of science, who make experiments on brute animals, perhaps merely from a sort of curiosity.” He pictured such an animal “fastened … pierced, gashed, and so left to linger out its life”. And he then asked, “Now do you not see that I have a reason for saying this, and am not using these distressing words for nothing? For what is this but the very cruelty inflicted upon our Lord?”

So it was as a sort of moral exercise that Newman first invoked those images of animal suffering, as a practice in sympathy, but also and expressly he was gripped by the images in themselves, and he used words for them as strong as a Christian could find: “there is something so very dreadful, so Satanic, in tormenting those who have never harmed us, and who cannot defend themselves, who are utterly in our power.” Satanic! This meant something shocking at that time, addressed to a congregation in which almost all must have been earnest believers, and many of the men in holy orders themselves (as college fellows commonly were). Newman was shifting the matter from the realm of personal sensibility (“horrible to read … distressing”), and into eschatology: death, judgement, heaven and hell. He could not at that time have condemned vivisection more absolutely or more permanently.

Soon after that, Newman left Oxford, exiled by his decision to be ordained into the Roman Catholic Church. And subsequently the religious preoccupations which so vitally engaged him and others during the nineteenth century have ebbed away, from Oxford University and elsewhere. The meaning which the pictured monkey holds for humanity and our self-explanation, in its character as our forebear, probably commands now a larger congregation than the meaning of Easter does, supposing that they have to be at odds. At any rate, the idea that Christ’s sufferings, real and terrible as they historically were, constituted a sacrifice ‘purchasing our salvation’ is a hard one to accommodate in science-minded western culture. Still, as the picture of the monkey shows, we’re not done with sacrificing as a principle. Indeed, George Bernard Shaw believed that a primitive trust in propitiatory sacrifice was what really persuaded the modern public of the efficacy of vivisection, in so far as it was persuaded.

But there’s more to the comparison than just that ancient habit of making others pay our debts. When we see another species of primate, we get as near as we may to looking at our own genesis. Ecce homo, in fact (the Latin version of words ascribed to Pontius Pilate: see the note below). The last lines of Karen Joy Fowler’s novel We Are All Completely Beside Ourselves (discussed in the post for 10 September 2015), record the narrator’s encounter with a confined chimpanzee, bullet-proof glass between them: “I recognized everything about her … As if I were looking in a mirror.” But we have heard from this woman’s brother that such recognition is only the start in finding who we really are. Referring to the absurdly over-rated ‘mirror test’ for animal self-consciousness (essentially a test of human-likeness), he has told her, “We need a sort of reverse mirror test. Some way to identify those species smart enough to see themselves when they look at someone else. Bonus points for how far out the chain you can go. Double points for those who get all the way to insects.” So other primates are the go-betweens, who both are and show our relation to all the other animals beyond themselves, and therefore to life itself. In putting them to death in this way, we offend against life our own maker, and, as children of nature not God, we condemn ourselves with no means of forgiveness. This is the story that the monkey photograph tells.

If you can, be in Birmingham on Saturday and speak up for the equal holiness, beauty, and right to freedom of all life.

 

Notes and references:

World Day for Animals in Laboratories was instituted in 1979, the particular date being the birthday of Hugh Lord Dowding, whose work for animals is discussed in the post for 26 June, at https://voiceforethicalresearchatoxford.wordpress.com/2016/06/26/a-servant-of-the-state-of-nature/

The Lush report can be read here: http://lushprize.org/wp-content/uploads/Global_View_of-Animal_Experiments_2014.pdf

Newman’s sermon ‘The Crucifixion’ was collected in volume 7 of the eight-volume Parochial and Plain Sermons (quotations from pp.134-37 of the 1868 edition).

Quotations from We Are All Completely Beside Ourselves are from pp.308 and 201-2 of the U.K. edition (Profile Books, 2014).

The painting is by Alberto Mantagna, dated 1500 and titled Ecce Homo. “Ecce homo!” is what Pilate exclaims when he presents Jesus to the crowd (in the Latin Vulgate translation of John 19.5). The common English version would be ‘Behold the man!’, but the Latin can equally mean ‘Behold mankind!’

I don’t know the source of the WDAIL photograph.